By Sonia B. Jakowlew, M.B. Sporn
Reworking development issue- ß in melanoma remedy, Vols. 1 and a couple of, presents a compendium of findings concerning the function of remodeling development issue- ß (TGF- ß) in melanoma remedy and treatment. the 1st quantity, simple and scientific Biology, is split into 3 elements. This volume’s spouse, melanoma remedy in treatment, examines remodeling progress issue- ß in different constructing and complicated cancers and strategies of remedy and remedy.
Read Online or Download Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology (Cancer Drug Discovery and Development) PDF
Similar cell biology books
Telomerases, telomeres, and cancer
This quantity offers huge insights to the latest discoveries in telomere biology, with present purposes in tumor diagnostics and destiny potentials in remedy. distinct gains of numerous organisms are provided, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; together with crops and bugs besides.
This instruction manual on vacuolar and plasma membrane H+-ATPases is the 1st to target an important hyperlink among vacuolar H+-ATPase and the glycolysis metabolic pathway to appreciate the mechanism of diabetes and the metabolism of melanoma cells. It provides fresh findings at the constitution and serve as of vacuolar H+-ATPase in glucose selling meeting and signaling.
Microglia Biology, Functions and Roles in Disease
The pioneering experiences by means of a number of best researchers within the early a part of the final century first defined the life of microglial cells either within the early mind improvement and in pathological stipulations. Microglial cells have been later tested to be the resident mind macrophages and immunocompetent cells current ubiquitously within the vital frightened approach together with the retina in organization with different glial cells, neurons and blood vessels.
Best Investigators discover the Complexities of Angiogenesis melanoma examine The concentrating on of tumor angiogenesis has developed into the most greatly pursued healing suggestions. notwithstanding, as of but, no antiangiogenic agent used as a monotherapy has proven a survival profit in a randomized section III trial.
- Lysosomal Pathways of Protein Degradation (Molecular Biology Intelligence Unit)
- The Molecules of Life: Physical and Chemical Principles
- Mesenchymal Stromal Cells. Translational Pathways to Clinical Adoption
- Amniotic Membrane: Origin, Characterization and Medical Applications
- Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues
Additional info for Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology (Cancer Drug Discovery and Development)
Example text
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-f family of receptor serine-threonine kinases. J Biol Chern 2001 ;276: 19,332-19,339. 156. Hocevar BA, Smine A, Xu X-X, Howe PH. The adaptor molecule Disabled-2links the transforming growth factorB receptors to the Smad pathway. EMBO J 2001;20:2789-2801. 157. Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA. TGF-p-inducd apoptosis is mediated by the adaptor protein Daxx that facillitates JNK activation. Nat Cell Biol 2001 ;8: 708-714.
J Biol Chern 1999;274:37,413-37,420. 172. Hocevar BA, Brown TL, Howe PH. TGF-~ induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 1999;18: 1345-1356. 173. Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor p-mediated epithelial to mesenchymal transition and cell migration. J Biol Chern 2000;275:36,803-36,810. 174. Petritsch C, Beug H, Balmain A, Oft M.
Genomics 1995;28:356-357. 48. Mathew S, Murty VVVS, Cheifetz S, George D, Massague J, Chaganti RSK. Transforming growth factor receptor gene TGFBR2 maps to human chromosome band 3p22. Genomics 1994;20: 114-115. 49. Kim S-J, Glick A, Sporn MB, Roberts AB. Characterization of the promoter region of the human transforming growth factor-S! gene. J Biol Chern 1989;264:402-408. 50. Geiser AG, Kim S-J, Roberts AB, Sporn MB. Characterization of the mouse transforming growth factor-Ill promoter and activation by the Ha-ras oncogene.