By Suguru Nakamura
This guide on vacuolar and plasma membrane H+-ATPases is the 1st to target an important hyperlink among vacuolar H+-ATPase and the glycolysis metabolic pathway to appreciate the mechanism of diabetes and the metabolism of melanoma cells. It offers contemporary findings at the constitution and serve as of vacuolar H+-ATPase in glucose selling meeting and signaling. It additionally describes the regulatory mechanisms of vacuolar H+-ATPase in yeast cells, neural stem cells, kidney cells, melanoma cells, and lower than diabetic stipulations.
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Additional info for Handbook of H+-ATPases
Subsequent work in mammalian cells supports the idea that regulation of V-ATPase activity by altering its assembly state may be more universal. In immature dendritic cells, antigen proteolysis is inhibited by reduced lysosomal acidiﬁcation resulting in reduced processing of antigen. When maturation signals induce dendritic cells to process antigen, the level of assembly of the V-ATPase on the lysosomal membrane increases resulting in increased lysosomal acidiﬁcation, which is required for antigen processing .
1997). V1-situated stalk subunits of the yeast vacuolar protontranslocating ATPase, J Biol Chem, 272, pp. 26787–26793. 36. D. M. (1993). Partial assembly of the yeast vacuolar H(+)-ATPase in mutants lacking one subunit of the enzyme, J Biol Chem, 268, pp. 16845–16851. 37. J. (1996). Resolution of subunit interactions and cytoplasmic subcomplexes of the yeast vacuolar proton-translocating ATPase, J Biol Chem, 271, pp. 10397–10404. 38. , and Liu, J. (1999). Early steps in assembly of the yeast vacuolar H+ -ATPase, J Biol Chem, 274, pp.
Et al. (2010). PKA regulates vacuolar H+ -ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells, J Biol Chem, 285, pp. 24676–24685. 74. M. (2010). Vacuolar H+ -ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase, Am J Physiol Renal Physiol, 298, pp. F1162–F1169. 75. , and Breton, S. (2008). Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells, Am J Physiol Cell Physiol, 294, pp.