By Guido Krupp; Reza Parwaresch
This quantity presents extensive insights to the newest discoveries in telomere biology, with present functions in tumor diagnostics and destiny potentials in treatment. certain good points of numerous organisms are provided, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; together with vegetation and bugs to boot. 28 chapters have been written by way of a bunch of top learn scientists, operating within the telomere/telomerase fields at the present time. This e-book could be a middle reference for any health care professional, scientist or "educated reader" with an curiosity within the interesting advancements during this examine box
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This quantity offers vast insights to the newest discoveries in telomere biology, with present functions in tumor diagnostics and destiny potentials in treatment. exact gains of numerous organisms are awarded, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; together with vegetation and bugs besides.
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Extra info for Telomerases, telomeres, and cancer
The process of immortalisation is linked to telomere biology. Gradual erosion of telomeres, the very ends of human chromosomes, eventually limits the replicative life span of somatic cells and this process can be regarded as an ultimate tumor suppressor mechanism eliminating cells that have accumulated genetic alterations. The enzyme telomerase elongates telomeres and Telomeres and Telomerases: Cancer and Biology, edited by Guido Krupp and Reza Parwaresch. com and Kluwer Academic / Plenum Publishers.
Hayflick L. Exp Cell Res 1965; 37:614-636. 7. Wille JJ Jr, Pittelkow MR, Shipley GD et al. Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum-free medium: clonal analyses, growth kinetics, and cell cycle studies. J Cell Physiol 1984; 121:31-44. The Role of Telomerase De-Regulation in Keratinocyte Immortality 21 8. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990; 345:458-460. 9. Dickson MA, Hahn WC, Ino Y et al.
1995; 13:254-265. 2. Loughran O, Malliri A, Owens D et al. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: Relationship of dysfunction to immortality and neoplasia. Oncogene. 1996; 13:561-568. 3. Loughran O, Clark LJ, Bond J et al. Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes. Oncogene. 1997; 14:1955-1964. 4. McGregor F, Wagner E, Felix D et al. Inappropriate retinoic acid receptor-beta expression in oral dysplasias: correlation with acquisition of the immortal phenotype.