By Axel Brehmer
The enteric worried approach comprises quite a few diverse neuron populations which belong to 3 major teams, basic afferent neurons, interneurons and effector neurons. the main broad wisdom at the varied enteric neuron kinds is derived from experiences within the guinea-pig. an important concern for the move of this data to putative similar enteric neurons of different species, together with human, is species variations as to their morphological, chemical, physiological and so forth. phenotypes. sleek morphological classifications are according to the paintings of the Russian histologist Dogiel. because the overdue 1970’s, sophisticated morphological classifications of enteric neurons past Dogiel were tried mostly in species, the guinea-pig and the pig. those mirror the immunohistochemical range of enteric neurons extra accurately yet are faraway from being entire. during this paper, we goals. to begin with, we current an summary at the chemical coding of the morphological neuron kinds defined via Stach within the pig gut. In doing so, we now have mentioned the adaptation among the definitions of kind I neurons given by way of Dogiel and Stach. Secondly, we try to supply a foundation for the morpho-chemical class of human enteric neurons as published through their immunoreactivity for neurofilaments and several other neuroactive ingredients or comparable markers.
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Additional info for Structure of Enteric Neurons
Example text
C A type III neuron (III; arrow indicates axon) is negative for cChAT (C’; empty III) but positive for the peripheral choline acetyl transferase (pChAT; C’). Arrowed scale bars (50 µm) point orally in A, B and C 30 Chemical Coding of Stach’s Neuron Types in the Pig Type IV Neurons 31 chemically, the population of type III neurons as presently defined, seems to be heterogeneous. Immunohistochemically, both serotonin (Scheuermann et al. 1991) and nNOS, but no co-localization of the substances could be demonstrated in type III-like neurons (Timmermans et al.
Note that one axon of the lower type II neuron (marked by two axons) enters the disrupted interconnecting strand (arrowhead). C Of the four NF-reactive type II neurons in A, two are positive (II) and two are negative (empty II) for the peripheral choline acetyl transferase (pChAT; C’) whereas all neurons are positive for cChAT (C”; II). Arrowed scale bars (50 µm) point orally in A, B and C Type II Neurons 27 28 Chemical Coding of Stach’s Neuron Types in the Pig has later been confirmed by electrophysiological experiments in type II neurons of the guinea pig (Hendriks et al.
1993; Porter et al. 1996; Sang and Young 1998; Hens et al. 2000). Recently, a novel antibody against a peripheral form of ChAT has been characterized, the peripheral ChAT (pChAT; Tooyama and Kimura 2000) in contrast to the common ChAT (cChAT). The forms of ChAT differ in their mRNA; however, the pChAT protein displays regions which are suspected to be essential for its catalytic function. It has been demonstrated that the newly raised antibody against pChAT did not stain brain regions of known cholinergic nature but revealed a number of peripheral, including enteric, neurons (Tooyama and Kimura 2000; Nakajima et al.