By Vincent Béringue
This booklet incorporates a choice of chapters aimed to supply a greater figuring out prion constitution and biology. jointly those chapters supply an outline of prion biology and underscore a number of the demanding situations we are facing if we wish to know how this vigorous pathogen propagates and evolves in mammals. there's additionally mounting proof that learning prion biology has a much wider relevance as a result of similarities in the Read more...
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181, 551–565 (2008). 16. Gadotti, V. , Bonfield, S. , and Zamponi, G. W. Depressive-like behavior of mice lacking cellular prion protein. Behav. , in press. © 2013 by Apple Academic Press, Inc. 14 Prion Biology: Research and Advances 17. Latremoliere, A. and Woolf, C. J. Central sensitization. A generator of pain hypersensitivity by central neural plasticity. J. Pain, 10, 895–926 (2009). 18. Woolf, C. J. and Salter, M. W. Neuronal plasticity. Science, 288, 1765–1769 (2000). 19. Herrero, J. , Laird, J.
Neuronal plasticity. Science, 288, 1765–1769 (2000). 19. Herrero, J. , Laird, J. , and López-García, J. A. Wind-up of spinal cord neurones and pain sensation. Much ado about something? Prog. , 61, 169–203 (2000). 20. , and Navarro, X. Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Exp. , 217, 84–95 (2009). 21. Yoshimura, M. and Yonehara, N. Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injuryevoked neuropathic pain.
On mechanical withdrawal threshold. M. (n = 6 - 12). 001. 4 CONCLUSION In summary, our data indentify PrPC as an important negative regulator of pain signaling. Considering that PrPC physically interacts with the receptor complex to depress current amplitude, it may perhaps be possible to mimic this inhibition with small organic molecules interacting at the PrPC interaction site on the receptor. 1 Statistical Analysis Data were presented as means ± SEM and evaluated by t-tests, two-way or three-way analysis of variance (ANOVA) followed by Tukey test when appropriate.