By D.F. Hochstrasser, R. D. Appel, K. L. Williams, Marc R. Wilkins, Keith L. Williams, Ron D. Appel, Denis F. Hochstrasser
Contemporary advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic research of proteins and their post-translational differences from any tissue or organism attainable. This strategy has received the identify "Proteome Research", and will be regarded as the middle of sensible genomics. the result of proteome research express which genes are expressed, how the protein items are transformed, and the way they have interaction, making proteome learn of basic value for the biologist, clinician, and pharmaceutical undefined.
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Extra info for Proteome Research: New Frontiers in Functional Genomics (Principles and Practice)
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MRNA sequences that have intramolecular structures involving the SD or the initiation codon should be avoided. 2. A long (five to eight nucleotides) SD is favorable for translation. 3. The spacing between the SD and the initiation codon is important but depends on the length and sequence of the SD. As a result of the precise distance between the 3' end of the 16s rRNA and the binding sitefor the initiator tRNA inthe ribosome, longer spacing is more tolerable than shorter spacing. 4. AUG is most favorable as an initiation codon.
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