By Liza A. Pon, Eric A. Schon (Eds.)
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Cockroach (Periplaneta americana) flight muscle mitochondria are prepared according to Novak and colleagues (1979). 4, using 10 ml of medium per 3 g of tissue. Homogenization consists of 12 up-and-down strokes in a 1-min period. Fractions are then separated by low-speed centrifugation (2000g for 20 min) or by high-speed centrifugation (10,000g for 10 min). Fractions obtained with these centrifugations are composed mainly of mitochondria. Centrifugation of the homogenate at 18,500g for 20 min yields a fraction containing mitochondria and membranes of other origin.
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