By Gregory L. Blatch
The Networking of Chaperones by way of Co-chaperones updates the present realizing of ways chaperones are regulated and networked. it's a source for these within the really good box of phone pressure and chaperones. The ebook can also be of curiosity to these in broader cross-cutting box reminiscent of mobile networks and platforms biology.
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Additional info for The Networking of Chaperones by Co-chaperones (Molecular Biology Intelligence Unit)
Sample text
7,8,63,65 By titrating the relative level ofXap2 protein in cells, AhR activity can be enhanced or decreased. 66 Displacement of p23 by high levels ofXap2 would destabilize binding of Hsp90 to AhR and reduce the proportion ofAhR in functionally mature complexes. 67-71 Finally, several studies suggest that Xap2 facilitates nucleocytoplasmic shuttling ofAhR following ligand binding. 71' 75 The physiologicalrelevanceofXap2 interactions with AhR complexeshas not been examined in a whole animal model , but Xap2 could potentially influence any ofseveral physiological and pathological pathways mediated by AhR.
41. Baughman G, Wiederrecht GJ, Campbell NF et al. FKBP51, a novel Tvcell-specific immunophilin capable of calcineurin inhibition . Mol Cell Bioi 1995: 15(8):4395-4402. 42. Kester HA, van der Leede BM, van der Saag PT et al. Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of brea st cancer cells coincides with enhancement of differen tiation . J Bioi Chern 1997: 272(26):16637-16643. 43. Zhu W, Zhang JS, Young CY.
Za Networking o/Chaperones by Co-Chaperones, edited by Gregory L. Blatch. ©2007 Landes Bioscience and Springer Science-Business Media. 8 The chaperone activity of Hsp70 is regulated by co-chap erones, which usually act by modifying the ATPase cycle of Hsp70. Hsp70 in the ATP bound state has a lower affinity for substrates than the ADP bound state . 9 Hsp40 proteins are well-known co-chaperones of Hsp70, regulating the activity ofHsp70 by stimulating its ATP hydrolysis step (see Chapter by Rosser and Cyr).