By Federico Calegari, Claudia Waskow
The first quantity of Stem Cells offers with the elemental ideas that govern embryonic and somatic stem mobile biology. traditionally, the identity and characterization of such pathways and common principles of stemness happened in the course of embryonic improvement and quantity I displays this with subject matters spanning cellphone cycle law, epigenetics, and uneven mobile department in a few organ platforms from planarian to human. 3 particular sections speak about i) easy Stem mobile Biology, ii) Tissue Formation in the course of improvement, and iii) version Organisms with specific emphasis on these extra proper for biomedical learn and, therefore, resulting in the subjects addressed in quantity II.
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Extra resources for Stem Cells: From Basic Research to Therapy, Volume 1: Basic Stem Cell Biology, Tissue Formation during Development, and Model Organisms
Example text
It was also, through Blumenbach, an impetus for Immanuel Kant to clearly distinguish the properties of organisms from those of inanimate objects. One century later, regeneration was a challenge for those who tried to elaborate a theory of heredity. Darwin included it in the model of pangenesis he elaborated in 1868. Thomas Morgan spent many years studying regeneration before his conversion to genetics. He saw the study of regeneration as an alternative and original way to address the question of development.
The culmination of these discoveries resulted in the awarding of the Nobel Prize in physiology or medicine to Drs. Leland Hartwell, Tim Hunt, and Sir Paul Nurse in 2001. In this chapter, we will begin with a basic introduction of the cell cycle and pluripotent stem cells and continue by describing the unusual properties of the cell cycle of pluripotent stem cells. We will further discuss recent discoveries and control mechanisms of the cell cycle in pluripotent cells, such as regulation by Myc and miRNAs, and conclude by addressing some of the major questions that are still unresolved.
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