By Lester Packer (Eds.)
Nitric oxide, lately named''Molecule of the Year''by the magazine Science, impinges on quite a lot of fields in organic examine, relatively within the components of biomedicine and mobilephone and organismal biology, in addition to in primary chemistry. This quantity and its better half quantity 269 spotlight the most up-tp-date and up to date tools used to analyze the body structure and toxicity of nitric oxide in mobile and organismal platforms. it will likely be a worthy resourcefor the skilled researcher in addition to for these newly coming into the sector.
Key Features
* iteration, detection, and characterization of organic and chemical assets of nitric oxide
* Biochemistry and molecular biology of enzymes and proteins linked to nitric oxide metabolism
Read Online or Download Nitric Oxide Part A: Sources and Detection of NO; NO Synthase PDF
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Extra info for Nitric Oxide Part A: Sources and Detection of NO; NO Synthase
Sample text
Valeri, and J. Loscalzo, Proc. Natl. Acad. Sci. A. 89, 7674 (1992). 6i B. Gaston, J. Reilly, J. M. Drazen, J. Fackler, P. Ramdev, D. Arnelle, M. E. Mullins, D. J. Sugarbaker, C. Chee, D. J. Singel, J. Loscalzo, and J. S. Stamler, Proc. NatL Acad. Sci. A. 90, 10957 (1993). [3] DIRECT AND INDIRECT EFFECTS OF NO 23 derived relaxing factor). 62 The reactivity of sulfhydryls toward NOx is 106 times greater than toward nucleic acids and 10 3 times greater than toward other amino acids except tyrosine.
Laval, J. Laval, J. A. Cook, M. C. Krishna, W. DeGraff, and J. B. Mitchell, Chem. Res. Toxicol. 7, 519 (1994). 57 D. A. Wink and P. C. Ford, Methods (San Diego) 7, 14-20 (1995). 58 M. N. Routledge, D. A. Wink, L. K. Keefer, and A. Dipple, Chem. Res. Toxicol. 7, 628 (1994). 59 M. B. Grisham and A. M. Miles, Biochem. PharmacoL 47, 1897 (1994). 22 SOURCES AND DETECTIONOF NO [31 N O + 02 OONO" NO ONO-ONO Gas Phase / NO2 I +NO N203 n2o ~ 2 NO Aqueous Phase "N203" NO2- tt+ Flo. 1. Mechanistic aspects of the autoxidation of NO.
Mechanistic aspects of the autoxidation of NO. Sulfhydryl-containing proteins such as glutathione have a high affinity for this intermediate, forming S-nitrosothiol adducts [Eq. (18)]56: R S H + NOx ~ R S N O + NO2- (18) These adducts have been shown to form endogenously in the cardiovascular and p u l m o n a r y system. 6°,61 These S-nitrosothiol adducts release N O over a period of time and activate guanylate cyclase in vivo and have even been p r o p o s e d as an alternative chemical species to N O as E D R F (endothelium60 j.