By Y. C. Lee, Reiko T. Lee (Eds.)
Neoglycoconjugates aren't in simple terms worthwhile for the fundamental figuring out of protein-carbohydrate interactions, yet they've got many useful functions besides. they're strong reagents in lots of phone biology stories and ideal instruments for the isolation and characterization of animal and plant lectins, separation of cells, in addition to for the concentrating on of gear, synthetic vaccines, and diagnostic reagents. quantity 247 and its spouse quantity 242 comprise many functional tools on tips to arrange and use neoglycoconjugates. quantity 242 bargains with synthesis and 247 with biomedical functions
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Additional resources for Neoglycoconjugates, Part B: Biomedical Applications
Example text
85. 56. 5 Hz, 1H, H-I, Fuc). 88 (C-I, Fuc). 45 (B). 67. 13. 8 Hz, IH. 5 Hz, 1H, H-4, Gal). 81 (C-I, Gal). 2 mmol). 2 mmol), is added. 5 M HCI and saturated NaHCO3 solution and with saturated NaC1 solution, dried with MgSO4, and concentrated in vacuo. The crude product 34 or 40, respectively, is crystallized by addition of ! : 1 (v/v) diethyl ether/light petroleum ether and purified by flash chromatography in ethyl acetate. 28 (B). 93, C! 43. 36. 5 Hz, 2H, H-4, H-4, Fuc). 65 (C- 1, Fuc). 29 (B).
3 Hz, 1H, Asn-o~-Hy. 8 Hz, 2H, H-4, H-4, Fuc). 55 (C-l, Fuc). 75 (B). 40. 51. 85 (d. 7 Hz, 2H, H-4, H-4, Gal). 69 (C-l, Gal). Benzyloxycarbonylalanylserylalanine tert-butyl ester is synthesized according to conventional Z-tert-butyl strategy 39'4°and subsequently sub39 E. Schr6der and E. Klieger, Liebigs Ann. Chem. 673, 208 (1964). 40 W. Grassmann and E. Wiinsch, Chem. Ber. 91, 462 (1958). 33 (CH3OH). 200 MHz tH N M R (DMSO-d6): 6 I. b = 6 . 0 Hz, 1H, Ser-NH, Ala-NH). 43 (amide, ester C = O ) .
Res. 155, C 6 (1986). 07 (t, J3,4 = J3,2 = 9 . 5 Hz, 1H, H-l, Fuc). 93 (C-l, Fuc). 2- A cetamido-4 ,6- O- benzylidene- 2-deoxy- 3-O-( 2,3 ,4- tri- O-acetyl- I~ -fucopyranosyl)-~-D-glucopyranosylazide (8). 5 g, 30 mmol). The orange-colored solution is stirred at room temperature until 7 is no longer detectable by TLC. After addition of saturated NaHCO3 solution, the solvent is evaporated in vacuo; the remaining residue is dried by codistillation with toluene and finally dried under high vacuum. The residue is dissolved in pyridine (100 ml).