By Professor David Latchman
This e-book has compatible intensity and insurance, nice for an individual that feels that Lewin's GENES is just too long. It has first-class reference lists for one that desires to be aware of extra. It has transparent diagrams and used to be written elegantly. but it isn't up-to-date often.
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I. (1999). A sampling of the yeast proteome. Molecular and Cellular Biology 19, 7357–7368. M. E. (1983). Protein blotting: principles and applications. Analytical Biochemistry 131, 1–15. B. O. (1976). The expression of three abundance classes of messenger RNA in mouse tissues. Cell 9, 761–774. K. (1970). Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227, 680–685. J. A. (2000). Genomics, gene expression and DNA arrays. Nature 405, 827–836. H. (1975).
Thus, for example, once the gene for myosin has been eliminated from an antibody-producing B-lymphocyte it will not be possible for such a cell, whatever the circumstances, to give rise to a myosin-containing muscle cell. Although the requirement for such a change from one differentiated cell type to another is not likely to occur in normal development, such a phenomenon, known as transdifferentiation, has been achieved experimentally in Amphibia (Yamada, 1967). Thus, if the lens is surgically removed from an eye of one of these organisms, some of the neighboring cells in the iris epithelium lose their differentiated phenotype and begin to proliferate.
9) would involve the selective amplification of genes that were expressed at high levels in a particular tissue, the high expression of such genes simply resulting from normal rates of transcription of the multiple copies of the gene. 2). Thus, although amplification of intestine-specific genes would have occurred in such cells, this would presumably not prevent the amplification of other tissue-specific genes in the individual cell types of the new organism. The evidence against this idea comes therefore from chromosomal and molecular rather than functional investigations.