By Clemens Sonntag
Realizing of the molecular foundation of DNA harm and its fix has elevated dramatically in recent times, and vast wisdom now exists in regards to the items bobbing up from free-radical assault on DNA. Free-radical DNA harm could lead to mutations, melanoma, and mobilephone dying. unfastened radicals have quite a few assets, significantly ionizing radiation and oxidative tension. In radiotherapy for melanoma and with a few anticancer medications, use is made up of mobilephone demise through over the top DNA harm. The mechanisms resulting in items of free-radical assault that have been studied in versions and with small double-stranded DNA fragments are mentioned intimately, and the fundamentals of the underlying free-radical chemistry are handled in separate chapters.
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Additional info for Free-Radical-Induced DNA Damage and Its Repair
Sample text
The disulfide is not photostable, but slowly isomerizes to its head-to-tail isomer [reactions (62) and (63)], and in subsequent reactions is converted into the betaine [reactions (64) and (65)] which is the photocatalytic agent that causes the oxidation of the guanine moiety (Adam et al. 1999). Thus, considerable care has to be taken not to misinterpret photobiological studies using this • OH-source. A further caveat has been expressed by Douki et al. (1999) who observed that product ratios are considerably different when ionizing radiation and N-hydroxypyridine-2-thione were used as • OH sources, and this has been explained by the H-donating property of the N-hydroxypyridine2-thione (note the major dimers mentioned above).
1987). This may potentially be due to its reaction with A, for which there is increasing evidence that • OH are generated at one stage of the reaction sequence (Ishizaki et al. 1984; Theruvathu et al. 2001a). Thus, ozone may be included into the reagents that cause DNA damage by a free-radical pathway, although most of the ozone reactions that have been studied so far are non-radical in nature. Ozone is a strongly electrophilic reagent (for a compilation of rate constants, see Neta et al. 1; Hoigné and Bader 1983).
Radiat Environ Biophys 39:179–188 Bar-Or D, Winkler JV (2002) Copper is involved in hydrogen-peroxide-induced DNA damage. Free Radical Biol Med 32:197–198 Barat F, Hickel B, Sutton J (1969) Flash photolysis of aqueous solutions of azide and nitrate ions. Chem Commun 125–126 Barbouti A, Doulias P-T, Zhu B-Z, Frei B, Galaris D (2001) Intercellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage. Free Radical Biol Med 31:490–498 Bartels DM, Crowell RA (2000) Photoionization yields vs energy in H2O and D2O.