By William B. Guggino (Eds.)
The volume of recent details at the molecular biology of chloride channels has grown enormously lately. this massive volume of knowledge offers a few precise and, in a few cases, astonishing insights into the functionality and constitution of chloride channels that are found in each telephone. This quantity includes a sequence of in-depth reports of chloride channel body structure, biophysics, and molecular biology. The studies disguise chloride channels present in the plasma membrane in addition to in organelles of either plant and animal cells. Key positive aspects* Discusses CFTR, the cystic fibrosis transmembrane regulator, that is accountable for CF and the CIC-family of chloride channels chargeable for myotonia congenita* In-depth studies of chloride channel body structure, biophysics, and molecular biology* studies chloride channels present in the plasma membrane and in organelles of either plant and animal cells
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1970). Stomata1 responses to pressure changes and interruptions in the water supply of detached leaves of Zea mays L. Plant Physiol. 45, 415-423. Raschke, K . (1979). Movements using turgor mechanisms. Encycl. , New Ser. 7, pp. 383-441. , and Hedrich, R. (1990). Patch-clamp measurements on isolated guard-cell protoplasts and vacuoles. I n “Methods in Enzymology” (S. Fleischer and B. ). Vol. 174, pp. 312-330. Academic Press, San Diego. Redhead, C. , Edelman, A. , Brown. D.. Landry. D. W . and Al-Awqati.
A . 85,436-440. Skerrett. M.. and Tyerman, S. D. (1994). A channel that allows inwardly directed fluxes of anions in protoplasts derived from wheat roots. Planta 192, 295-305. Speer, M.. and Kaiser. W. M. (1991). Ion relations of symplastic and apoplastic space in leaves from Spiniucia oleracia L. and Pisum satiuirm L. under salinity. Plant Physiol. 97, 990-997. , Shimmen. , and Mimura, T. (1987). Membrane control in the Characeae. Annu. Rev. Plant Physiol. 38, 95-1 17. Terry, B. R.. Tyerman, S.
Myotonia (muscle stiffness) is a symptom of several human inheritable diseases (Rude1and Lehmann-Horn, 1985). , the eye, the CNS, and the heart. , 1992). Phosphorylation of different targets in different tissues could explain the multitude of symptoms in myotonic dystrophy. In contrast, autosomal recessive generalized myotonia (GM, Becker’s myotonia) (Becker, 1977) and autosomal dominant myotonia congenita (MC, Thomsen’s disease) (Thomsen, 1876)are purely myotonic diseases. Here symptoms are restricted to skeletal muscles.