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Cell-wide metabolic alterations associated with malignancy by Lorenzo Galluzzi, Guido Kroemer

24 February 2017 adminCell Biology

By Lorenzo Galluzzi, Guido Kroemer

This new quantity of tools in Enzymology keeps the legacy of this most efficient serial with caliber chapters authored by means of leaders within the box. This quantity covers examine tools offering a a theoretical review on metabolic adjustments of melanoma cells and a sequence of protocols that may be hired to review oncometabolism, in vitro, ex vivo and in vivo.   Malignant cells show metabolic alterations in comparison to their basic opposite numbers, because of either genetic and epigenetic changes. even though this type of metabolic rewiring has lately been indicated as ''yet another'' basic hallmark of melanoma, amassing proof means that the metabolic adjustments of every neoplasm relatively signify a molecular signature that in detail accompanies, and for that reason can't be severed from, all aspects of malignant transformation.

  • Continues the legacy of this most well known serial with caliber chapters authored by way of leaders within the field
  • Covers learn equipment in biomineralization science
  • Contains sections on such themes offering a a theoretical evaluation on metabolic adjustments of melanoma cells and a sequence of protocols that may be hired to check oncometabolism, in vitro, ex vivo and in vivo.

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Extra resources for Cell-wide metabolic alterations associated with malignancy

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Transcriptional mechanisms underlying lymphocyte tolerance. Cell, 109(6), 719–731. , & Kappler, J. (2004). Control of T cell viability. Annual Review of Immunology, 22, 765–787. Marsden, V. , & Strasser, A. (2003). Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annual Review of Immunology, 21, 71–105. Matheu, M. , & Cahalan, M. D. (2007). Dissection and 2-photon imaging of peripheral lymph nodes in mice. Journal of Visualized Experiments, (7), 265. , Hogan, P. , et al.

Gwack, Y. (2012). Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proceedings of the National Academy of Sciences of the United States of America, 109(22), 8682–8687. , Jung, H. , Kim, K. , & Gwack, Y. (2010). A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nature Cell Biology, 12(5), 436–446. Stiber, J. , & Rosenberg, P. B. (2011). The role of store-operated calcium influx in skeletal muscle signaling.

Et al. (2007). Biochemical and functional characterization of Orai proteins. Journal of Biological Chemistry, 282(22), 16232–16243. , Hogan, P. , Lamperti, E. , et al. (2008). Hair loss and defective T and B cell function in mice lacking ORAI1. Molecular and Cellular Biology, 28(17), 5209–5222. , & Marrack, P. (2007). Apoptosis and the homeostatic control of immune responses. Current Opinion in Immunology, 19(5), 516–521. Hildeman, D. , Mitchell, T. , et al. (2002). Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

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Pomme Pidou Library > Cell Biology > Cell-wide metabolic alterations associated with malignancy by Lorenzo Galluzzi, Guido Kroemer
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