By Roy Zent, Ambra Pozzi
Cancer used to be idea to originate from adjustments in intercellular signaling that led to the transformation of cells, their out of control proliferation and metastasis. there's now an expanding physique of facts demonstrating that the encompassing matrix and cell-matrix interactions also are significant gamers during this strategy. Cells adhere and obtain indications from a number of extracellular matrices through transmembrane receptors, the simplest recognized of that are the heterodimeric glycoproteins, integrins.
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