By M Sluyser
In apoptosis within the mammalian method, cells have a finite existence - they improve, are used after which die. melanoma cells break out this programmed regimen yet, from an figuring out of apoptosis, they are often programmed to die. This ebook addresses the
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Extra resources for Apoptosis In Normal Development And Cancer
269, 18877–18880. , KIEFHABER, T. X. (1989) Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 337, 476–478. , HAYANO, T. & SUZUKI, M. (1989) Pedtidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 337, 473–475. , WITZEL, B. M. (1991) Is ENZYMOLOGY OF APOPTOSIS 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 31 cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?
1993) Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 777 tissue: apoptosis or recrosis. Am. J. Pathol. 142, 935–946. 30 48 49 50 51 52 53 54 55 56 57 58 59 60. 61 62 63 64 65 66 67 APOPTOSIS IN NORMAL DEVELOPMENT AND CANCER . M. A. (1986) Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid. Endocrinology 118, 38–45. , ORRENIUS, S. & JONDAL, M. (1989) Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.
Thus, it is possible that individual signalling pathways activate specific nucleases which precipitate an apoptotic cascade; however, such tailor-making of enzyme to a particular signal would surely amount to a great cost to the cell. Therefore, it is likely that, if multiple enzymes can bring an apoptotic genome to an appropriate end, then the number of such readily available nucleases is small. Given the redundancy of biological systems, and the importance of maintaining a functional apoptotic pathway in a given cell, such a limited but multiple enzyme hypothesis should be considered.