By Abel Lajtha, Glen Baker, Susan Dunn, Andrew Holt
The instruction manual is meant to be a provider to the neuroscience group, to assist to find to be had and invaluable details, to indicate gaps in our wisdom, and to inspire persisted reviews. It represents the dear contributions of the various authors of the chapters and the advice of the editors and most vital, it represents aid for examine during this self-discipline. in accordance with the fast advances within the years because the moment variation
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Extra info for Lajtha. Handbook of Neurochemistry and Molecular Neurobiology
Example text
1996). , 1994). , 2001). 2 Non‐benzodiazepines Buspirone, gepirone, and ipsapirone are non‐BZD anxiolytics and structurally belong to the azapirone group of compounds. They have in common a major metabolite namely, 1‐(2 pyrimidinyl) piperazine (1‐PP). Investigators have reported methods for the determination of all these compounds and their common metabolite (1‐PP) by RP‐HPLC. Studies by Odontiadis and Franklin (1996) have shown the simultaneous determination of buspirone and 1‐PP using RP‐HPLC with coulometric electrochemical detection.
Studies have shown that extraction of TCAs and associated metabolites from their plasma matrices can be achieved using CN, C2, or C18 bonded phase cartridges using 1 ml of plasma. The chromatographic determination was usually performed using either a cyano‐propyl or C18 analytical column with UV/VIS detection. The LLOQs reported were in the range of 5–15 ng/ml. , 2002). , 2004). 2 Selective serotonin reuptake inhibitors (SSRIs) and other newer antidepressants Due to their widely differing structures in comparison to TCAs, several methods for their determination in biological matrices have been developed for each compound individually.
Metabolic routes include S‐oxidation, aromatic hydroxylation, N‐dealkylation, N‐oxidation, and a combination of these processes. Chlorpromazine, for example, possesses 168 possible metabolites, a large proportion of which are pharmacologically active compounds. The development of an HPLC assay capable of resolving a large number of these metabolites is virtually impossible and assays that permit the simultaneous determination of the parent compound and a selected number of active metabolites must suffice.