By Kim T. Blackwell (Eds.)
Progress in Molecular Biology and Translational Science presents a discussion board for dialogue of recent discoveries, methods, and ideas in molecular biology. It comprises contributions from leaders of their fields and ample references. This quantity brings jointly assorted facets of, and ways to, molecular and multi-scale modeling, with functions to a various diversity of neurological diseases.
Mathematical and computational modeling bargains a robust technique for reading the interplay among molecular pathways and ionic channels in generating neuron electric task. it's good authorized that non-linear interactions between varied ionic channels can produce unforeseen neuron habit and prevent a deep figuring out of the way ion channel mutations lead to irregular habit and sickness. Interactions with the various signaling pathways activated via G protein coupled receptors or calcium inflow provides an extra point of complexity. Modeling is an method of combine myriad info resources right into a cohesive and quantitative version as a way to overview hypotheses approximately neuron functionality. particularly, a confirmed version constructed utilizing in vitro facts permits simulations of the reaction to in vivo like spatio-temporal styles of synaptic enter. Incorporating molecular signaling pathways into an electric version, permits a better variety of versions to be constructed, ones which can expect the reaction to prescribed drugs, lots of which aim neuromodulator pathways.
- Contributions from prime experts
- Informs and updates on all of the most modern advancements within the field
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Example text
35 Genetic mutation studies, however, have some limitations. First, it is unknown whether also additional factors are involved, for example, compensatory upregulation of other Na channels, role of channel-binding partners, modifier genes, epigenetic factors, etc. Second, it is reasonable to assume that the more general sources of pain, trauma, inflammation, and metabolic disorders include changes in more than one ion channel. Taken together, this would call for a multifactorial approach to address pain symptoms [A].
2012;7:e44388. 42. Yakovenko S, Gritsenko V, Prochazka A. Contribution of stretch reflexes to locomotor control: a modeling study. Biol Cybern. 2004;90:146–155. 43. Saltelli A, Chan K, Scott EM. Sensitivity Analysis. New York, NY: Wiley; 2008. CHAPTER THREE Implications of Cellular Models of Dopamine Neurons for Schizophrenia Na Yu*, Kristal R. Tucker†, Edwin S. Levitan†, Paul D. Shepard{, Carmen C. Canavier* *Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA † Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA { Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA Contents 1.
Saltelli A, Chan K, Scott EM. Sensitivity Analysis. New York, NY: Wiley; 2008. CHAPTER THREE Implications of Cellular Models of Dopamine Neurons for Schizophrenia Na Yu*, Kristal R. Tucker†, Edwin S. Levitan†, Paul D. Shepard{, Carmen C. Canavier* *Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA † Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA { Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA Contents 1.