By Mihaly Nogradi
Книга Stereoselective Synthesis: a realistic procedure Stereoselective Synthesis: a realistic ApproachКниги Химия Автор: Mihaly Nogradi Год издания: 1994 Формат: pdf Издат.:Wiley-VCH Страниц: 387 Размер: 14,5 ISBN: 3527292438 Язык: Английский0 (голосов: zero) Оценка:The state of the art in stereoselective synthesis!Thoroughly revised and up to date, this enlarged moment version bargains a plethora of worthwhile details on tools and reagents in stereoselective synthesis. tools were chosen for top potency and selectivity; mechanistic points are taken care of succinctly, with a powerful emphasis on sensible functions. For this re-creation, fabric has been additional on* homogeneous diastereoselective hydrogenations* enantioselective oxidations* novel, effective chiral auxiliariesMuch of the data given is gifted in figures and tables, which makes the ebook a precious reference paintings for the virtually minded natural chemist.From experiences of the 1st edition:'The huge fabric within the quantity may still turn out relatively valuable to a person keen on artificial chemistry or instructing a path in natural chemistry.' magazine of Medicinal Chemistry 'With approximately 1400 references stated, the publication encompasses a wealth of knowledge and will be an invaluable addition to the chemist's library.' the yankee Scientist
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Extra resources for Stereoselective Synthesis: A Practical Approach
Example text
1-7. Kinetic resolution as a function of time. builds up. This excess goes through a maximum and disappears on completion of the reaction (Fig. 1-7). If the reaction is interrupted before completion or if less than the necessary amount of reagent is applied, the result is a non-racemic mixture of the starting material and of a product in which an excess of the more reactive enantiomer of the substrate is incorporated. This way of partial separation of enantiomers is called kinetic resolution. The main types of kinetic resolution will be discussed below.
G. the formation of 14 in Fig. 1-11). Since the ground state free energy of diastereomers is different, the observed product ratio is either the result of unequal rates of formation (kinetically controlled selectivity) or subsequent equilibration (thermodynamically controlled selectivity) or of both. Formation of a pair of enantiomers from a single substrate always involves the transformation of enantiotopic groups or faces. When such groups or faces interact with an achiral agent two different transition states arise which are related as mirror images.
Finally, we summarize the present state of knowledge concerning the mechanism of the reaction. 1. I Chiral Phosphorus Containing Ligands Ligands containing one or two phosphorus atoms of the phosphine, phosphinite and aminophosphine type, with chirality at phosphorus or carbon have been synthesised. Chiral ligands may also be incorporated into a polymer. Altogether, the preparation and testing of well over a hundred different ligands has been reported [25]. Most of them, however, have been applied only with a few standard substrates, most often with (2)-2-acetamido- and (2)-2-benzamidocinnarnic acid, their methyl esters, 2-acetaminoacrylic acid, and itaconic acid.