By Henrik Hellquist, Alena Skalova
Over the final 25 years it has develop into progressively more glaring that salivary gland pathology is by means of some distance the topic inside head and neck pathology that motives such a lot diagnostic demanding situations and difficulties for common pathologists. in the course of classes the writer has given, experts and trainees alike have expressed the inability of a complete, precious ebook on salivary gland pathology. this sort of publication has to be huge and to demonstrate virtually each variation of all tumor entities. one other vital characteristic to include is the newly won wisdom approximately genetics in salivary gland tumors, a data that has emerged over the last 3-4 years in simple terms (and is becoming continuously). A mapping of the immunophenotypes of salivary gland tumors is neither on hand this present day and should drastically profit in regimen diagnostic work.
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Additional info for Histopathology of the Salivary Glands
Example text
Oncocytic change in dilated ducts of laryngeal seromucinous glands is not exceptional, and laryngeal oncocytic cystic lesions are a rather frequent incidental findings in laryngectomy specimens [2, 11, 21, 41, 49, 50, 55, 61] (Fig. 8). Clear cell metaplasia occurs primarily in different salivary gland tumours but can also be seen in normal 1 Histology 14 Fig. 7 Sebaceous metaplasia. Note the proximity to intercalated ducts (top and left) a b c d Fig. 8 (a) Parotid gland with multifocal nodular oncocytic metaplasia with four larger and three smaller rather distinct whitish/yellowish nodules.
Chronic sclerosing sialadenitis is hence characterised by atrophy or destruction of glandular lobules, marked lymphoplasmacytic infiltration admixed with irregular and dense fibroplasias and obliterative phlebitis. More than 45 % of infiltrating IgG-positive plasma cells are of IgG4-type which is in sharp contrast to sialadenitis seen in cases of sialolithiasis and Sjögren’s syndrome where less than 5 % of IgG-positive plasma cells are of IgG4-type [86]. 3 Sialadenitis and Sialadenosis nosis of IgG4-related disease.
The majority of the lymphocytes consists of CD3+ T cells, whilst CD20+ B cells are mainly restricted 44 in small nodules. CD8+ T cells predominate over CD4+ T cells [106]. There is hence a rather significant dominance of cytotoxic T cells contrary to chronic non-irradiation sialadenitis where CD4+ subsets predominate, and which are mainly periductal and not periacinar. The serous cells are the most sensitive and the first to be destroyed which has been linked to their content of secretory granules.