By Marília Afonso Rabelo Buzalaf (ed.)
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24 Olympio KP, Bardal PA, Cardoso VE, Oliveira RC, Bastos JR, Buzalaf MA: Low-fluoride dentifrices with reduced pH: fluoride concentration in whole saliva and bioavailability. Caries Res 2007;41:365–370. 25 Wilson AC, Bawden JW: Salivary fluoride concentrations in children with various systemic fluoride exposures. Pediatr Dent 1991;13:103–105. 26 Whitford GM, Thomas JE, Adair SM: Fluoride in whole saliva, parotid ductal saliva and plasma in children. Arch Oral Biol 1999;44:785–788. 27 Weidmann SM, Weatherell JA: The uptake and distribution of fluorine in bones.
Despite this, the amelogenesis in the 129P3/J strain was remarkably unaffected by fluoride [83]. Dental fluorosis-associated quantitative trait loci were detected on mouse chromosomes 2 and 11. Histological examination of maturing enamel showed that fluoride treatment resulted in accumulation of amelogenins in the maturing enamel of A/J mice, but not of 129P3/J mice [84]. The physiological, biochemical and/ or molecular mechanisms underlying this resistance remain to be determined. In humans, the possibility of gene-environment interaction was assessed by determining differential susceptibility to fluorosis at a given level of fluoride exposure based upon genetic background.
146 Chankanka O, Levy SM, Warren JJ, Chalmers JM: A literature review of aesthetic perceptions of dental fluorosis and relationships with psychosocial aspects/oral health-related quality of life. Community Dent Oral Epidemiol 2010;38:97–109. 147 Australian Research Centre for Population Oral Health: The use of fluorides in Australia: guidelines. Aust Dent J 2006;51:195–199. 148 Rozier RG, Adair S, Graham F, Iafolla T, Kingman A, Kohn W, Krol D, Levy S, Pollick H, Whitford G, Strock S, Frantsve-Hawley J, Aravamudhan K, Meyer DM: Evidence-based clinical recommendations on the prescription of dietary fluoride supplements for caries prevention.