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Additional info for Dopaminergic Ergot Derivatives and Motor Function. Proceedings of an International Symposium Held in the Wenner–Gren Center, Stockholm, July 24–25, 1978
Reflex mechanisms in parkinsonian rigidity have also been investigated by Burke, Hagbarth and Wallin (1977), who found that spindle afferent responses in PD looked like those of normal subjects who were not fully relaxed and in whom there was co-activation of skeletomotor and fusimotor systems. It was suggested that parkinsonian rigidity may well result primarily from a lack of modulation of cortical motor output due to a disturbed inhibitory feedback from basal ganglia, and that there is no evidence of a primary defect of the fusimotor system.
Ergoline It is from this skeleton that those substances have been derived which have so far been found to possess more or less marked central dopaminergic activity. , Farmitalia) and in the USA (Cassady, Floss and Kornfeld, Eli Lilly). The most interesting preparations at present are shown in Fig. 6 (see next page). To complete the picture, mention must be made of a special group of ergolines with prolactin-inhibitory activity. These are naturally occurring ergolines which have been given the name "clavine".
Campochiaro and J. T. Coyle, Ontogenetic development of kainate neurotoxicity, Proc. Natl. Acad. Sei. USA, 75, 2025 (1978). 34. R. Kobayashi, M. Brown and W. Vale, Regional distribution of neurotensin and somatostatin in rat brain, Brain Res. 126, 584 (1977). 35. M. Brownstein, A. Arimura, H. Sato, A. V. Schally and J. S. Kizer, The regional distribution of somatostatin in the rat brain, Endocrinology 96, 1456 (1975). 36. G. R. Uhl, M. J. Kuhar and S. H. Snyder, Neurotensin: immunohistochemical localization in rat central nervous system, Proc.