By Hugh Devlin
Univ. Dental clinic of Manchester, united kingdom. advisor to the foundations of entire denture development. Illustrated and useful, this article contains a variety of tactics intimately so the dentist can practice the easiest therapy degree to a selected medical challenge. Illustrations are in complete colour.
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Explored the potential role of genetics in the development of ONJ in MM patients under BP therapy. A genome-wide association study was performed analyzing 500,568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treated MM patients, one with and the other without ONJ. Four SNPs that mapped within the cytochrome P450-2C gene (CYP2C8) showed a different distribution between cases and controls, with statistically significant differences. SNP rs1934951 was significantly associated with a higher risk of ONJ development.
References 1. Rogers MJ, Gordon S, Benford HL et al (2000) Cellular and molecular mechanism of action of bisphoshonate. Cancer 88:2961–2978 2. Roger MJ (2003) New insights into the molecular mechanism of action of bisphosphonates. Curr Pharm Des 9:2643–2658 3. Russell RG (2007) Bisphosphonates: mode of action and pharmacology. Pediatrics 119: S150–S162 4. Russell RG (2006) Bisphosphonates: from bench to bedside. Ann NY Acad Sci 1068: 367–401 5. Chapurlat RD, Delmas PD (2006) Drug insight: bisphosphonates for postmenopausal osteoporosis.
Musolino and A. Allegra it has decreased the frequency of skeletal events in MM and delayed their development . Multiple myeloma is the second most common hematologic malignancy and the most common malignancy to involve bone, as more than 85% of patients with MM have bone involvement, which can be devastating. Approximately 45% of patients with MM experience a fracture in the first year after diagnosis, and 65% experience a fracture during the course of the disease [3, 4]. Advanced MM is accompanied by bone lesions resulting from the heightened osteolytic activity of osteoclasts and decreased rates of osteogenesis by osteoblasts.