By Mario Pagliaro
This is the 1st ebook to deal with the new subject of practical silica gels and their functions. initially used mostly in chromatography, really good silica gels have developed into crucially very important useful nanomaterials compatible to be used in, among different issues, chemical synthesis, research, purification, floor defense and drug release.
The booklet demonstrates how chemists synthesize, from the bottom-up, tailored (nano) fabrics of significant sensible significance spanning the fields of chemistry, physics, fabrics technological know-how, engineering, biology and medication. It additionally indicates how the flexibility of silica gels effects from their actual and chemical houses. An up to date outlook on new advertisement items, and the corporations which cause them to, significantly provides relevance and functional price to the text.
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Extra info for Silica-Based Materials for Advanced Chemical Applications
Example text
The advantages of this drug delivery technology are evident in terms of safety (silica is a biocompatible natural component of the body, does not affect the pH of the surrounding tissues, reducing risk of inflammation) and enhanced performance (encapsulation is suitable for synthetic small molecular compounds and for biopharmaceuticals; the 46 Chapter 2 resulting solid matrix biodegrades, can be shaped in variable forms and delivery times can be adjusted from days to several months). 9). 9 Cumulative release of heparin from silica xerogel matrix with varying drug concentration.
Each data point represents the mean of three samples and error bars are standard deviations. (Reproduced from ref. 10 47 Cumulative release of heparin from methyltriethoxysilane-modified silica xerogel matrix. Each data point is the mean of three samples and error bars are standard deviations. (Reproduced from ref. ) characteristics for the mechanism of drug release after the initial release. By plotting ln(Mt À M2/MN) versus ln(t À t2), nB can be calculated from the slope of the curve. The values of nB describing release after the initial release are characteristic for the drug release mechanism.
The products are supplied as aqueous dispersions containing approximately 35% (w/w) of the UV absorber. 0 mm diameter on average. 5 mm in diameter, and are thus sufficiently small to be transparent when applied to the skin and to give a pleasant feeling. The dispersion consists of water, UV filter, silica, poly(vinyl pyrrolidone) and chlorphenesin, and shows excellent physical stability up to 80 1C and does not freeze. 2. The aqueous microemulsion dispersion provides new opportunities for cosmetic formulators, as oil-soluble organic sunscreens can now be incorporated into the aqueous phase, and incompatibilities between cosmetic ingredients can be prevented to the benefit of novel combinations in a single cosmetic product.