By Robert K. Yu, Cara-Lynne Schengrund
A thorough creation is supplied to the diversity and complexity of the jobs that glycoconjugates play within the cells of the apprehensive method. easy info in addition to the most recent advancements in neural glycobiology are mentioned. themes lined diversity from the constitution and metabolism of the saccharide chains and present techniques utilized in their learn, to adjustments glycoconjugates suffer in the course of improvement and getting older of the anxious process and the jobs they've got in neurological disorder. The breadth and intensity of issues lined make it a necessary reference for these new to the sphere in addition extra professional investigators.
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Sample text
In: Fukuda M, Hindsgaul O, editors. Molecular and Cellular Glycobiology. Oxford: Oxford University Press; 2000. p. 1–61. Fukuda MN, Hakomori S. Structures of branched blood group A-active glycosphingolipids in human erythrocytes and polymorphism of A- and H-glycolipids in A1 and A2 subgroups. J Biol Chem. 1982;257(1):446–55. Fukuda MN, Bothner B, Scartezzini P, Dell A. Isolation and characterization of poly-Nacetyllactosaminylceramides accumulated in the erythrocytes of congenital dyserythropoietic anemia type II patients.
2010;21(6):622–30. Nandini CD, Sugahara K. Role of the sulfation pattern of chondroitin sulfate in its biological activities and in the binding of growth factors. Adv Pharmacol. 2006;53:253–79. Nishimura S. Toward automated glycan analysis. Adv Carbohydr Chem Biochem. 2011;65: 219–71. P. C. Gowda North SJ, Hitchen PG, Haslam SM, Dell A. Mass spectrometry in the analysis of N-linked and O-linked glycans. Curr Opin Struct Biol. 2009;19(5):498–506. Orlando R. Quantitative analysis of glycoprotein glycans.
The glycoconjugates are abundantly found in extracellular matrix and on cell surfaces, where the glycan moieties participate in numerous biological interactions, which are crucial for differentiation and development and life of the organism. Therefore, abnormal glycan metabolism leads to disease pathogenesis. Ironically, many pathogens and toxins produced by them exploit the cell surface glycans to attach and invade cells, causing debilitating and fatal disease. Acknowledgments We thank Dr. Rajeshwara Achur for the preparation of Figs.