By Henry N. Claman
...the writing is superb...the most intricate immunologic approaches are provided in easy-to-folow diagrams...clinicians who take care of girls attempting to have infants, graduate scholars, postdoctoral fellows, and scientific citizens needing a easy wisdom of being pregnant immunology might locate this ebook a invaluable asset.-The New England magazine of drugs
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Extra resources for The Immunology of Human Pregnancy
Sample text
Hematopoietic cell differentiation is controlled by colony-stimulating factors (CSFs) and a number of these are made by lymphoid cells, including G-CSF (granulocyte-CSF) and GM-CSF (granulocyte-monocyte CSF). These pathways provide connections between the immune and the hematopoietic systems. Still other cytokines such as tumor necrosis factors (TNF a and ~) and transforming growth factor ~ (TGF-~) are important in inflammation, tumor cell control, and cell growth regulation. 13 Immunoglobulins The immunoglobulin family of molecules consists of 5 members, IgG, IgA, IgM, IgD, IgE.
9,lO The gene products do associate with B microglobulin and so comprise a somewhat different kind of RCA class I molecule. HLA-G a.
The trophoblasts survived even in a presensitized host, but the embryos did not. Therefore they believed that the trophoblast was weak or lacking in antigenicity. " Simmons and Russell concluded from their important functional studies that histocompatibility antigens (about which little was known in 1962) were either absent from the trophoblast or were not expressed in an immunogenic manner. When reagents became available that could identify human MHC antigens by immunohistochemical means, these reagents were used to explore MHC expression in the placenta.