By Marshall Phillips; Albert Baetz
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Extra info for Diet and Resistance to Disease
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63:463-468. Nungester, W. , and Ames, A. M. (1948) The relationship between ascorbic acid and phagocytic activity. J. Infect. Disease 83:50-54. Olsen, G. , and Polk, H. c. (1977) In vitro effect of ascorbic acid on corticosteroid-caused neutrophil dysfunction. J. Surgical Res. 22:109-112. Oyanagui, Y. (1976) Inhibition of superoxide anion production in macrophages by anti-inflammatory drugs. Biochem. Pharmaco1. 25:1473-1480. Pauling, L. (1976) Vitamin C and the common cold. Medical Tribune, March 24:1-4.
M. (1973) Enhancement of the humoral immune response by vitamin E, Intern. Arch. Allergy, 44:221. ANTI-INFLAMMATORY, IMMUNOLOGIC AND CARCINOSTATIC ATTRIBUTES OF SELENIUM IN EXPERIMENTAL ANIMALS Julian E. Spa11ho1z Department of Food and Nutrition Texas Tech University Lubbock, Texas 79409 INTRODUCTION In the author's opinion there are three major historical benchmarks in the evolution of our knowledge about the element of the moon, selenium (Se), since its discovery by Berze1ius in 1817 (Fredga, 1972).
The dose response effect of Se when added to the diets of mice or guinea pigs for immune enhancement appears to be 1-2 ppm as indicated by the PFC assay performed with mice and the DNCB challenge of guinea pigs. , id, sc or ip. A comparison of the animals and the quantity of selenium administered by injections is also indicative of species variably in the dose-response relationship for immune enhancement. In addition, in no experiment has immunoenhancement of circulating antibodies been observed when Se was administered after immunization.