By Leon Speroff MD, Philip D. Darney MD MSc
"The completely up-to-date 5th variation of this functional instruction manual is a present, trustworthy, and readable consultant to the clever use of modern contraceptive ideas. The authors give you the crucial details that clinicians and sufferers have to opt for the easiest contraceptive approach for the patient's age and scientific, social, and private features. The publication concisely covers all to be had medicines and devices. �Read more...
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Extra info for A Clinical Guide for Contraception
Sample text
Raymond from the Rockefeller Institute to serve as director of research, working in new laboratories in Skokie, Illinois. Dramamine, to prevent motion sickness, and Banthine, to treat peptic ulcers, came from these laboratories. D. 17 Pincus and Oscar Hechter had developed a perfusion method, pumping blood, serum, or a serum-like solution through fresh endocrine glands (adrenal glands, testicles, or ovaries) held in a glass apparatus and collecting the perfused fluid. Using the enzymes in the glands, precursors in the perfusing fluid were converted to the final products, hydrocortisone or the sex steroids.
Rock was a physician who literally transformed his personal values in response to his recognition of the problems secondary to uncontrolled reproduction. With the help of Luigi Mastroianni, the first administration of synthetic progestins to women was to Rock’s patients in 1954. Of the first 50 patients to receive 10 to 40 mg of synthetic progestin (a dose extrapolated from the animal data) for 20 days each month, all failed to ovulate during treatment (causing Pincus to begin referring to the medication as “the pill”), and 7 of the 50 became pregnant after discontinuing the medication, again pleasing Rock, who all along was motivated to treat his infertile patients.
But one must be cautious regarding the clinical significance of subtle changes, and it is unlikely there will be a major impact. A second group of progestins became available for use when it was discovered that acetylation of the 17-hydroxy group of 17-hydroxyprogesterone produced an orally active but weak progestin. An addition at the 6 position is necessary to give sufficient progestational strength for human use, probably by inhibiting metabolism. Derivatives of progesterone with substituents at the 17 and 6 positions include the widely used medroxyprogesterone acetate.